Birth: Valladolid, December 21, 1956. Qualification: Doctor of Chemical Sciences from the University of Valladolid in 1982. Thesis Director: Prof. Ángel Alberola Figueroa. Position and Current Position: Professor of Organic Chemistry in the Department of Chemistry of the University of Burgos since 1998, full-time dedication. Previous positions: Assistant in the Department of Organic Chemistry of the Faculty of Sciences of the University of Valladolid, from 1978 to 1982. Lecturer in the Department of Organic Chemistry in the Faculty of Veterinary Medicine of the University of Extremadura, from 1983 to 1998. Dean of the Faculty of Sciences of the University of Burgos from 2000 to 2004. Director of the Organic Chemistry Area of the Chemistry Department of the University of Burgos 1999-2017. Main research topics: Sulfur-Nitrogen Heterocyclic Compounds, Multicomponent Reactions, Chemical Sensors, Supramolecular Chemistry. Web of Science finds 146 publications, with 4212 citations, h-index: 33, from them 40 publications in the last ten years, 90% in the first quartile. In the last ten years (2013-2023) the total number of publications is 40 and the number of publications in the first quartile is 90% of the total, with an average of 4 annual publications. Selected WOS articles in the last years: 1 article in Nature Chemistry (Imp. Fact. 24.3), 1 article in Nature Communications (Imp. Fact. 17.7), 1 article in Journal of the American Chemical Society (Imp. Fact. 15.4), 1 article in Journal of Materials Chemistry A (Imp. Fact. 14.5), 1 article in Green Chemistry (Imp. Fact. 11.0), 1 article in ACS Applied Materials and Interfaces (Imp. Fact. 10.4), 1 article in Chemical Science (Imp. Fact. 10.0), 1 article in Materials Chemistry Frontiers (Imp. Fact. 8.7), 1 article in Chemical Record (Imp. Fact. 6.9), 5 articles in Chemical Communications (Imp. Fact. 6.1), 4 articles in Organic Letters (Imp. Fact. 6.0), 3 articles in Inorganic Chemistry (Imp. Fact. 5.4), 1 article in Polymer Chemistry (Imp. Fact. 5.4), 1 article in Bioorganic Chemistry (Imp. Fact. 5.3), 1 article in Dyes and Pigments (Imp. Fact. 5.2), 7 articles in Chemistry-A European Journal (Imp. Fact. 5.0), 1 article in Molecules (Imp. Fact. 4.9), 1 article in Chemistry-An Asian Journal (Imp. Fact. 4.8), 1 article in Dalton Transactions (Imp. Fact. 4.6), 2 articles in Journal of Organic Chemistry (Imp. Fact. 4.1), 2 articles in 4 articles in Organic & Biomolecular Chemistry (Imp. Fact. 3.4), 2 articles in Inorganica Chimica Acta (Imp. Fact. 3.1), 1 article in ChemistryOpen (Imp. Fact. 2.6), 2 articles in Tetrahedron (Imp. Fact. 2.4). Research sections (sexenios) evaluated positively: 6: 1986-1991 (Sci., Positive), 1992-1997 (Sci., Positive), 1998-2003 (Sci., Positive), 2004-2009 (Sci., Positive), 2010-2015 (Sci., Positive), 2013-2018 (Technology Transfer, Positive), 2016-2021 (Sci., Positive). Date last granted: 03/05/2022. THESIS: 10 PhD Thesis supervised during the last 10 years, 3 examples are:

1.- Andrea Revilla Cuesta: New AIE luminogens from the naphthalimide and peryleneimide series: assembly on nanostructured materials for explosive detection, Supervisor: Tomás Torroba Pérez, 06 October de 2023, “Sobresaliente cum laude”, started September 2020, 8 publications, 2 patents.

2.- Patricia Calvo Gredilla: Fluorogenic sensor materials derived from perylene-diimides: environmental and bio-imaging applications, Supervisor: Tomás Torroba Pérez, 29 September 2017, “Sobresaliente cum laude”, started July 2014, 8 publications, 3 patents. Currently working in a pharmaceutical industry.

3.- José García Calvo: Fluorescent probes and nanostructured materials for the detection of environmental toxins and the development of catalysts, Supervisor: Tomás Torroba Pérez, 21 September 2018, “Sobresaliente cum laude”, started July 2014, 9 publications, 4 patents. Currently working as a María Zambrano researcher at T. Torres group, UAM/IMDEA, Madrid.

Part C. RELEVANT MERITS (sorted by typology)

C.1. Publications.

1.- M. Spínola-Amilibia, R. Illanes-Vicioso, E. Ruiz-López, P. Colomer-Vidal, F. Rodriguez-Ventura, R. Peces-Pérez, C. F. Arias, T. Torroba, M. Solà, E. Arias-Palomo, F. Bertocchini (2023), Plastic degradation by insect hexamerins: Near-atomic resolution structures of the polyethylene-degrading proteins from the wax worm saliva, Science Advances, 9, eadi6813.

2.- A. Revilla-Cuesta, I. Abajo-Cuadrado, M. Medrano, M. M. Salgado, M. Avella, M. T. Rodríguez, J. García-Calvo, T. Torroba (2023), Silica Nanoparticle/Fluorescent Dye Assembly Capable of Ultrasensitively Detecting Airborne Triacetone Triperoxide: Proof-of-Concept Detection of Improvised Explosive Devices in the Workroom, ACS Applied Materials and Interfaces, 15, 32024−32036.

3.- A. Sanluis-Verdes, P. Colomer-Vidal, F. Rodriguez-Ventura, M. Bello-Villarino, M. Spinola-Amilibia, E. Ruiz-Lopez, R. Illanes-Vicioso, P. Castroviejo, R. Aiese Cigliano, M. Montoya, P. Falabella, C. Pesquera, L. Gonzalez-Legarreta, E. Arias-Palomo, M. Solà, T. Torroba, C. F. Arias, F. Bertocchini (2022), Wax worm saliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella, Nature Communications, 13, 5568.

4.- S. Lapcinska, A. Revilla-Cuesta, I. Abajo-Cuadrado, J. V. Cuevas, M. Avella, P. Arsenyan, T. Torroba (2021), Dye-modified silica–anatase nanoparticles for the ultrasensitive fluorogenic detection of the improvised explosive TATP in an air microfluidic device. Materials Chemistry Frontiers, 5 (23), 8097-8107.

5.- D. C. Romero, P. Calvo-Gredilla, J. García-Calvo, A. Diez-Varga, J. Vicente Cuevas, A. Revilla-Cuesta, N. Busto, I. Abajo, G. Aullón, T. Torroba (2021), Self-Assembly Hydrosoluble Coronenes: A Rich Source of Supramolecular Turn-On Fluorogenic Sensing Materials in Aqueous Media, Organic Letters, 23 (22), 8727–8732.

6.- N. Busto, J. García-Calvo, J. V. Cuevas, A. Herrera, J.-L. Mergny, S. Pons, T. Torroba, B. García (2021), Influence of core extension and side chain nature in targeting G-quadruplex structures with perylene monoimide derivatives, Bioorganic Chemistry, 108 (3), 104660.

7.- V. García-Calvo, J. V. Cuevas, H. Barbero, S. Ferrero, C. M. Álvarez, J. A. González, B. Díaz de Greñu, J. García-Calvo, T. Torroba (2019): Synthesis of a Tetracorannulene‐Perylenediimide that Acts as a Selective Receptor for C60 over C70. Organic Letters, 21 (15), 5803–5807.

8.- J. García-Calvo, T. Torroba, V. Brañas-Fresnillo, G. Perdomo, I. Cózar-Castellano, Y.-H. Li, Y.-M. Legrand, M. Barboiu (2019), Manipulation of Transmembrane Transport by Synthetic K+ Ionophore Depsipeptides and Its Implications in Glucose-Stimulated Insulin Secretion in β-Cells, Chemistry – A European Journal, 25 (39), 9287-9294.

9.- J. García-Calvo, P. Calvo-Gredilla, M. Ibáñez-Llorente, D. C. Romero, J. V. Cuevas, G. García-Herbosa, M. Avella, T. Torroba (2018): Surface functionalized silica nanoparticles for the off-on fluorogenic detection of an improvised explosive, TATP, in a vapour flow, Journal of Materials Chemistry A, 6 (10), 4416-4423.

10.- J. García-Calvo, P. Calvo-Gredilla, S. Vallejos, J. M. García, J. V. Cuevas-Vicario, G. García-Herbosa, M. Avella, T. Torroba (2018): Palladium nanodendrites uniformly deposited on the surface of polymers as an efficient and recyclable catalyst for direct drug modification via Z-selective semihydrogenation of alkynes, Green Chemistry, 20 (16), 3875-3883.

11.- J. Garcia-Calvo, V. Garcia-Calvo, S. Vallejos, F. C. García, M. Avella, J. M. García, T. Torroba (2016): Surface Coating by Gold Nanoparticles on Functional Polymers: On Demand Portable Catalysts for Suzuki Reactions, ACS Applied Materials and Interfaces, 8 (38), 24999–25004.

12.- J. García-Calvo, S. Vallejos, F. C. García, J. Rojo, J. M. García, T. Torroba (2016): A smart material for the in situ detection of mercury in fish, Chemical Communications, 52 (9), 11915-11918.

13.- B. Díaz de Greñu, J. García-Calvo, J. V. Cuevas, G. García-Herbosa, B. García, N. Busto, S. Ibeas, T. Torroba, B. Torroba, A. Herrera, S. Pons (2015): Chemical Speciation of MeHg+ and Hg2+ in Water Solutions and HEK Cells Nuclei by means of DNA Interacting Fluorogenic Probes. Chemical Science, 6 (7), 3757-3764.

14.- B. Díaz de Greñu, D. Moreno, T. Torroba, A. Berg, J. Gunnars, T. Nilsson, R. Nyman, M. Persson, J. Pettersson, I. Eklind, P. Wästerby (2014): Fluorescent Discrimination between Traces of Chemical Warfare Agents and Their Mimics. Journal of the American Chemical Society, 136 (11), 4125–4128.

C.2. Congresses.

1.- Oral communication, 15 min., T. Torroba, From fluorescent biomarkers to soft nanotransporters, S13-OC06, XXVIII Reunión Bienal de la Real Sociedad Española de Química (RSEQ) Granada, June 27-30, 2022.

2.- Oral communication, 5 min., T. Torroba, Host-Guest Molecular Recognition of a Tetracorannulene-Perylenediimide with Two Molecules of Fullerene-C60, SP23, 14th International Symposium on Macrocyclic and Supramolecular Chemistry, June 2-6, 2019, Lecce, Italy.

3.- Oral communication, 30 min., T. Torroba, Development of new chemical sensors and optical technologies for fast and sensitive detection of IEDs, Panel 4, “Advanced Stand-off Detection and Neutralization Technologies”, 4^th C-IED Technology Workshop, October 01-03, 2019, Counter Improvised Explosive Devices Center of Excellence, Madrid.

C.3. Research projects.

1. Reference: PID2022-142318NB-I00. Self-assembling depsipeptides on aggregation-induced emission luminogens as a new way to create programmable nanovesicles, soft nanocarriers and green functional nanomaterials (FLUONANOVESICLE). Principal investigator: Tomás Torroba. Financing entity: Agencia Estatal de Investigación, Proyectos de Generación de Conocimiento 2022, Ministerio de Ciencia e Innovación. Duration: 01/09/2023 – 31/08/2027. Funding received: 120,000.00 euros. Project status: granted.

2.- Reference: PDC2022-133955-I00. Assembly of an AIEgen-based Fluorescent Dye and Silica Nanoparticles for the Ultrasensitive Detection of TATP in Air: A Chemical Nose Prototype for Searching IEDs in Carrier Baggage Storage [IED-CHEMDOG]. Principal investigator: Tomás Torroba. Financing entity: Agencia Estatal de Investigación, Pruebas de Concepto 2022, Ministerio de Ciencia e Innovación. Duration: 01/12/2022 – 31/05/2025. Funding received: 115,000.00  euros. Project status: granted.

3.- Reference: PID2019-111215RB-I00. Development of new chemical sensors for fast and selective detection of improvised explosive devices [CHEMSIED]. Principal investigator: Tomás Torroba. Financing entity: Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación. Duration: 01/06/2020 – 31/05/2023. Funding received: 72,600.00 euros. Project status: granted.

4.- Reference: BU263P18. Title: Fluorescent probes in nanostructured materials for the detection and modification of environmental toxins or trace contaminants and their incorporation into therapeutic strategies [FLUONANO]. Principal investigator: Tomás Torroba. Financing entity: Junta de Castilla y León, Council of Education, European Regional Development Fund. Duration: 11/07/2018 – 31/10/2021. Funding received: 120,000.00 euros. Project status: granted.

5.- Reference: 2019/00122/001. Title: Preimplantation factor (PIF) in the treatment of type 2 diabetes mellitus (PIF-T2DM). Principal investigators: Germán Perdomo, Tomás Torroba. Financing entity: Fundacion Bancaria Caixa D. Estalvis I Pensions de Barcelona, La Caixa. Duration: 01/12/2020–30/11/2022. Funding received: 85,000.00 euros. Project status: granted.

6.- Reference: 2019/00122/001. Title: New strategies in the treatment of obesity and diabetes mellitus using the preimplantation factor (PIF) in murine preclinical models (DIABO-PIF). Principal investigators: Germán Perdomo, Tomás Torroba. Financing entity: Fundacion Bancaria Caixa D. Estalvis I Pensions de Barcelona, La Caixa. Duration: 01/06/2019 – 31/05/2021. Funding received: 85,000.00 euros. Project status: granted.

7.- Reference: SPS G5536. Title: Development of new chemical sensors and optical technologies for fast and sensitive detection of improvised explosives. Principal investigator: Tomás Torroba. Financing entity: NATO SPS Program – Multi-year research projects. Duration: 01/09/2018 – 01/09/2021. Funding received: 300,000.00 euros. Project status: granted.

8.- Reference: CTQ2015-71353-R. Title: Development of new fluorogenic molecular devices for the fast detection of highly harmful chemical and biological agents [FLUOROMOL]. Principal investigator: Tomás Torroba. Financing entity: Ministry of Economy and Competitiveness, General Directorate of Scientific and Technical Research, General Subdirectorate for Research Projects. Duration: 01/01/2016 – 31/12/2018. Funding received: 95,590.00 euros. Project status: granted.

9.- Project reference: SPIP2015-01820. Title: Fluorogenic detection and quantification of opioids in biological samples. Principal Investigator: Tomás Torroba. Financing entity: General Directorate of Traffic, Traffic area, mobility and road safety for the financial year 2015. Duration: 01/12/2015 – 01/12/2016 Funding received: 48,599.10 euros. Project status: granted.

10.- Project reference: FP7-SEC-2012-312411 SNIFFER. Title: SNIFFER: Sensory devices network for food supply chain security. Principal investigator: Andre Oliveira. Financing entity: European Community, Seventh Framework Program, EU FP7-SECURITY, Subprogramme area: SEC-2012.1.5-4. Contract type: Small or medium-scale focused research Project. Duration: 05/01/2013 – 04/30/2016 Participation: Principal researcher at the University of Burgos in Work Package 3, 6 & 7. Funding received: EU contribution: 2,720,029 euros. UBU budget: 224,698 euros. Project status: granted.

11.- Project reference: CTQ2012-31611. Title: Detection and discrimination of organic contaminants and metabolites of high environmental impact by means of fluorogenic probes. Principal investigator: Tomás Torroba. Financing entity: Ministry of Economy and Competitiveness, General Directorate of Scientific and Technical Research, General Subdirectorate for Research Projects. Fundamental research projects not oriented. Duration: 01/01/2013 – 12/31/2015. Financing received: 101,790 euros. Project status: granted.

C.4. Contracts, technological or transfer merits.

1.- A. Diez de la Varga, T. Torroba Pérez, P. Calvo Gredilla, D. C. Romero Velásquez, Perileno-3,4:9,10-tetracarboxidiimidas substituidas, procedimiento de preparación y su uso como fluoróforos modulables, Patente de invención con examen, ES2719503B2, 12.11.2019.

2.- S. Vallejos Calzada, J. M. García Pérez, F. García García, F. Serna Arenas, P. Calvo Gredilla, J. García Calvo, T. Torroba Pérez, V. García Calvo, P. M. Avella Romero, Obtención de nanopartículas metálicas mediante uso de copolímeros en forma de membrana, Patente de invención, ES2684426B1, 03.07.2019.

3.- G. García Herbosa, T. Torroba Pérez, J. V. Cuevas Vicario, V. García Calvo, J. García Calvo, Dispositivo para determinación fluorimétrica de aminas terciarias, Patente de invención, ES2684868B1, 09.07.2019.

4.- T. Torroba Pérez, G. García Herbosa, J. V. Cuevas Vicario, V. García Calvo, Detección por fluorescencia de aminas terciarias, Patente de invención con examen previo ES2626231B2. 16.01.2018.

5.- F. Fernández Lázaro, N. Zink Lorre, A. Sastre Santos, T. Torroba Pérez, P. Calvo Gredilla, J. García Calvo, 1-(Piperazin-n-ilaril)- y 1,7-Di(Piperazin-n-ilaril)Perileno-3,4:9,10-Tetracarboxidiimidas, procedimiento de preparación de las mismas y su uso como detectores de explosivos oxidantes, Patente de invención con examen, ES2619109B2, 27.09.2017.